Electron Microscopy Data Bank

EMD-38394

Download Map 3D View

The Cryo-EM structure of MPXV E5 apo conformation

Release date: May 1, 2024
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8xj6

Gan J, Zhang W

Cell Discov (2024) [ ]

Sample:

Monkeypox virus e5 (90 kDa, Protein from Monkeypox virus)
Zinc ion (65 Da, Ligand)
Monkeypox virus (Virus from Monkeypox virus)
Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
Amp phosphoramidate (426 Da, Ligand)

[Show more]

EMD-38395

Download Map 3D View

The Cryo-EM structure of MPXV E5 in complex with DNA

Release date: May 1, 2024
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 8xj7

Gan J, Zhang W

Cell Discov (2024) [ ]

Sample:

Monkeypox virus e5 (90 kDa, Protein from Monkeypox virus)
Magnesium ion (24 Da, Ligand)
Dna (70-mer) (21 kDa, DNA from Monkeypox virus)
Monkeypox virus (Virus from Monkeypox virus)
Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)

[Show more]

EMD-38396

Download Map 3D View

The Cryo-EM structure of MPXV E5 C-terminal in complex with DNA

Release date: May 1, 2024
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 8xj8

Gan J, Zhang W

Cell Discov (2024) [ ]

Sample:

Magnesium ion (24 Da, Ligand)
Dna (70-mer) (21 kDa, DNA from Monkeypox virus)
Monkeypox virus (Virus from Monkeypox virus)
Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
Monkeypox virus e5 (53 kDa, Protein from Monkeypox virus)

[Show more]

EMD-36651

Download Map 3D View

hOCT1 in complex with metformin in outward open conformation

Release date: March 27, 2024
Resolution: 4.14 Å
EM Method: Single-particle
Fitted PDBs: 8jts
Q-score: 0.333

Zhang S, Zhu A, Kong F, Chen J, Lan B, He G, Gao K, Cheng L, Sun X, Yan C, Chen L, Liu X

Cell Discov (2024) 10 pp. 30-30 [ DOI: doi:10.1038/s41421-024-00664-1 Pubmed: 38485705 ]

Sample:

Solute carrier family 22 member 1 (62 kDa, Protein from Homo sapiens)
Human organic cation transporter in compelx wtih metformin in outward open conformation (Complex from Homo sapiens)
Metformin (129 Da, Ligand)

EMD-36652

Download Map 3D View

hOCT1 in complex with metformin in outward occluded conformation

Release date: March 27, 2024
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 8jtt
Q-score: 0.289

Zhang S, Zhu A, Kong F, Chen J, Lan B, He G, Gao K, Cheng L, Sun X, Yan C, Chen L, Liu X

Cell Discov (2024) 10 pp. 30-30 [ DOI: doi:10.1038/s41421-024-00664-1 Pubmed: 38485705 ]

Sample:

Metformin (129 Da, Ligand)
Solute carrier family 22 member 1 (58 kDa, Protein from Homo sapiens)
Human organic cation transporter in compelx wtih metformin in outward occluded conformation (Complex from Homo sapiens)

EMD-36653

Download Map 3D View

hOCT1 in complex with metformin in inward occluded conformation

Release date: March 27, 2024
Resolution: 3.77 Å
EM Method: Single-particle
Fitted PDBs: 8jtv
Q-score: 0.346

Zhang S, Zhu A, Kong F, Chen J, Lan B, He G, Gao K, Cheng L, Sun X, Yan C, Chen L, Liu X

Cell Discov (2024) 10 pp. 30-30 [ DOI: doi:10.1038/s41421-024-00664-1 Pubmed: 38485705 ]

Sample:

Solute carrier family 22 member 1 (62 kDa, Protein from Homo sapiens)
Human organic cation transporter in compelx wtih metformin in inward occludded conformation (Complex from Homo sapiens)
Metformin (129 Da, Ligand)

EMD-36654

Download Map 3D View

hOCT1 in complex with nb5660 in inward facing partially open 1 conformation

Release date: March 27, 2024
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8jtw
Q-score: 0.468

Zhang S, Zhu A, Kong F, Chen J, Lan B, He G, Gao K, Cheng L, Sun X, Yan C, Chen L, Liu X

Cell Discov (2024) 10 pp. 30-30 [ DOI: doi:10.1038/s41421-024-00664-1 Pubmed: 38485705 ]

Sample:

Solute carrier family 22 member 1 (62 kDa, Protein from Homo sapiens)
Nanobody 56 (14 kDa, Protein from Lama glama)
Human organic cation transporter in compelx wtih nb5660 in inward facing partially open 1 conformation (Complex from Homo sapiens)

EMD-36655

Download Map 3D View

hOCT1 in complex with nb5660 in inward facing fully open conformation

Release date: March 27, 2024
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 8jtx
Q-score: 0.482

Zhang S, Zhu A, Kong F, Chen J, Lan B, He G, Gao K, Cheng L, Sun X, Yan C, Chen L, Liu X

Cell Discov (2024) 10 pp. 30-30 [ DOI: doi:10.1038/s41421-024-00664-1 Pubmed: 38485705 ]

Sample:

Solute carrier family 22 member 1 (62 kDa, Protein from Homo sapiens)
Nanobody 56 (14 kDa, Protein from Lama glama)
Human organic cation transporter in compelx wtih nb5660 in inward facing fully open conformation (Complex from Homo sapiens)

EMD-36656

Download Map 3D View

hOCT1 in complex with nb5660 in inward facing partially open 2 conformation

Release date: March 27, 2024
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8jty
Q-score: 0.479

Zhang S, Zhu A, Kong F, Chen J, Lan B, He G, Gao K, Cheng L, Sun X, Yan C, Chen L, Liu X

Cell Discov (2024) 10 pp. 30-30 [ DOI: doi:10.1038/s41421-024-00664-1 Pubmed: 38485705 ]

Sample:

Solute carrier family 22 member 1 (62 kDa, Protein from Homo sapiens)
Nanobody 56 (14 kDa, Protein from Lama glama)
Human organic cation transporter in compelx wtih nb5660 in inward facing partially open conformation (Complex from Homo sapiens)

EMD-36657

Download Map 3D View

hOCT1 in complex with spironolactone in outward facing partially occluded conformation

Release date: March 27, 2024
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 8jtz
Q-score: 0.45

Zhang S, Zhu A, Kong F, Chen J, Lan B, He G, Gao K, Cheng L, Sun X, Yan C, Chen L, Liu X

Cell Discov (2024) 10 pp. 30-30 [ DOI: doi:10.1038/s41421-024-00664-1 Pubmed: 38485705 ]

Sample:

Solute carrier family 22 member 1 (62 kDa, Protein from Homo sapiens)
Human organic cation transporter in compelx wtih spironolactone in outward facing partially occludded conformation (Complex from Homo sapiens)
Spironolactone (416 Da, Ligand)

Filter By

Filter By